Figure 2. CD4+ and CD8+ T cell-dependent control of MCMV in newborn mice.
Newborn C57BL/6 mice were injected i.p. with 200 PFU of MCMV on PND 1 and depleted for the indicated T cell populations every 3 days starting from PND 2. Organs were collected on PND 14, and viral titers were determined by plaque assay. Titers in the organs of individual mice are shown (circles, n= 6). Horizontal bars represent medians; data were analyzed using Mann–Whitney U test. Asterisks denote significant values: *P < 0.05; **P < 0.01; DL, detection limit.