Table 1.

Table summarizing the mechanisms by which obesity may contribute to initiating acute pancreatitis, thus increasing acute pancreatitis incidence, and also worsen acute pancreatitis outcome by increasing local and systemic injury

Role of obesity in initiating acute pancreatitis:
Increased cholelithiasis
high cholesterol: bile acid- crystal nucleation, number.
HTG
Unmasked primary HTG
Secondary HTG
Diabetes
associated HTG
increased cholelithiasis
Incretin based therapies
Therapeutic interventions for obesity
Weight loss (associated gallbladder stasis)
Bariatric surgery
Duodeno-jejunal bypass liner
Gastric balloons
Role of obesity in worsening acute pancreatitis outcomes:
Increased intrapancreatic fat: worse pancreatic necrosis
Increased peripancreatic fat: systemic unsaturated fatty acid toxicity resulting in respiratory, cardiovascular, renal failure

HTG, hypertriglyceridemia.