Fig.6.

(A) Schematic representation of the different antimicrobial efficacy resulting from antimicrobial bomb (silver nanoclusters conjugated with daptomycin) (left) or individual bactericide (physical mixture) (right). (B) Whole-body invasive and noninvasive fluorescence images of mice after IV injection of IRDye 800CW (top) or NIR-emitting GS-AuNPs (bottom). (C) Illustration of the surgical operation for the establishment of unilateral ureteral obstruction (UUO) mouse model (top) and representative whole-body noninvasive fluorescence images of sham operated mice or UUO mice injected with NIR-emitting GS-AuNPs (bottom). (D) Representative X-ray images of mice after IV injection of renal clearable GSAuNPs at various time points as compared to that of mice injected with two doses of diatrizoate meglumine (DM, clinical iodine contrast agent) at their maximum contrast enhancements (top); representative X-ray images of the urinary system in UUO mice after IV injection of the GSAuNPs (bottom). (E) Dynamic PET imaging of the renal clearance of ⁶⁴Cu labeled ultrasmall AuNPs (⁶⁴Cu-NOTA-Au-GSH) after IV injection in mice. (Adapted or reprinted with permissions from American Chemical Society for (A) Ref. [244], John Wiley and Sons for (B) Ref. [252], (C) Ref. [253], (D) Ref. [254] and (E) Ref. [256].)