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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Nano Today. 2018 Jul 19;21:106–125. doi: 10.1016/j.nantod.2018.06.006

Fig.9.

Fig.9.

(A) Dose effect on the renal clearance of ultrasmall GS-AuNPs after IV injection in CD-1 mice. (B) Illustration of the dose-dependent transport of GS-AuNPs in blood vessels: at low dose, GS-AuNPs marginate extensively and readily enter the extravascular space (top), while in the case of high dose GS-AuNPs tend to be confined in blood vessels with reduced extravasation (bottom), resulting in more rapid transport within blood vessels and higher renal clearance. (C) Schematic of the delivery of fluorescent gold nanoclusters (FANC) into live cells as biocompatible fluorescent labels via liposome complex method (top); confocal images of stained calf muscles from hindlimb ischemic mice injected with endothelial progenitor cells labeled with or without FANC at 7, 14 and 21 days post injection (bottom). (D) Confocal laser scanning microscopy images (left) and transmission electron microscopy images (right) of fluorescent AuNCs internalized by human dendritic cells. (Adapted or reprinted with permissions from John Wiley and Sons for (A and B) Ref. [321], American Chemical Society for (C) Ref. [322], Elsevier for (D) Ref. [285].)