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. 2019 May 28;60(4):451–465. doi: 10.1093/jrr/rrz032

Table 1.

MCF10A cytokine, chemokine and growth factor profiles induced by proton treatments

MCF10A non-tumorigenic mammary epithelial cells
24 h 48 h 72 h
Analytes 0.5 Gy 2 Gy 9 Gy 0.5 Gy 2 Gy 9 Gy 0.5 Gy 2 Gy 9 Gy
IL-1β 0.78 0.69 0.81 0.94 0.95 1.34 1.08 1.17 1.69
IL-6 0.91 0.83 0.86 0.82 0.98 2.48 0.78 0.97 2.89
TNF-α 0.78 0.65 0.83 0.96 0.94 1.32 1.08 1.21 1.53
IL-12 0.29 0.11 0.47 0.64 0.29 1.00 0.64 0.64 1.18
IFN-γ 0.82 0.71 0.82 0.95 0.94 1.23 1.07 1.17 1.39
IL-4 0.80 0.74 0.84 0.97 0.96 1.27 1.09 1.19 1.49
IL-10 0.43 0.32 0.54 0.43 0.49 1.24 0.60 0.94 1.18
IL-13 0.77 1.00 0.77 0.77 0.77 1.00 0.77 1.00 1.23
IL-8 0.99 0.87 1.06 1.17 1.28 2.15 1.37 1.65 3.69
MCP-1 0.77 0.65 0.67 1.31 1.11 1.12 3.53 4.56 3.11
MIP-1β 0.18 0.00 0.33 0.84 0.56 2.01 1.30 1.64 2.82
IL-2 0.72 0.60 0.75 0.90 0.87 1.23 0.99 1.11 1.38
IL-7 0.66 0.48 0.66 1.00 0.77 1.16 1.32 1.32 1.27
IL-17 0.68 0.56 0.78 1.04 0.96 1.70 1.27 1.47 2.20
G-CSF 0.70 0.57 0.79 0.99 0.90 1.91 1.22 1.61 3.77
GM-CSF 0.90 0.86 0.86 1.02 1.02 1.29 1.10 1.10 1.39

IL-5 was undetectable.

Values (in term of pg ml–1) were normalized using CM of untreated MCF10A cells.