Table 4.
Dose–volume statistics of CSI for patients under 15 years of age
| Patients <15 years of age ipCSI without VBS, mean (95% CI) | ||
|---|---|---|
| CTV for CSI | Homogeneity index | 0.063 (0.047–0.079) |
| Conformity index | 1.194 (1.058–1.330) | |
| Heart | Mean dose, Gy (RBE) | 0.5 (−0.2–1.3) |
| V20 (%) | 0.1 (−0.2–0.5) | |
| V10 (%) | 1.2 (−1.5–3.9) | |
| V5 (%) | 2.9 (−2.4–8.3) | |
| Lung | Mean dose, Gy (RBE) | 2.7 (1.7–3.8) |
| V20 (%) | 4.3 (0.6–7.9) | |
| V10 (%) | 10.3 (7.1–13.5) | |
| V5 (%) | 14.9 (11.3–18.4) | |
| Abdominal cavity | Mean dose, Gy (RBE) | 0.6 (0.2–1.0) |
| V20 (%) | 0.4 (−0.2–1.0) | |
| V10 (%) | 2.0 (0.3–3.7) | |
| V5 (%) | 3.8 (1.1–6.5) |
CSI = craniospinal irradiation, ipCSI = intensity-modulated proton craniospinal irradiation, VBS = vertebral body sparing, CI = confidence interval, CTV = clinical target volume, RBE = relative biological effectiveness.