Table 2. Screening of the Reaction Conditions for the Cascade Wacker/Allylation Sequencea.
entry | Pd | Cu | atmosphere | yield (%)b |
---|---|---|---|---|
1 | + | + | Ar | 70 |
2 | + | – | O2 | 56 |
3 | + | – | Ar | 69 |
4 | – | + | O2 | 0 |
5 | – | + | Ar | 0 |
6 | – | – | O2 | 0 |
7 | – | – | Ar | 0 |
All reactions were conducted with 0.194 mmol of 1 in DME (1.0 mL).
Determined by 1H NMR analysis using an internal standard.