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. Author manuscript; available in PMC: 2019 Jul 19.
Published in final edited form as: J Cancer Treatment Diagn. 2018 Oct 9;2(5):11–16. doi: 10.29245/2578-2967/2018/5.1136

Figure 2:

Figure 2:

Schematic structure of Src and AhR interaction and phosphorylation. The AR protein contain an N-terminal domain (NTD); DNA-binding domain (DBD); and ligand-binding domain (LBD). AF-1, AF-5, AF-2 are three known transactivation domains in the AR. The Src molecule AR interacts with the AF-5 domain of AR through the SH3 (helix recognition) domain of cSrc. This interaction occurs following phosphorylation of Tyr416 and dephosphorylating of Tyr527 which is located in a C-terminal regulatory domain.