Figure 3:

The proposed pathway for constitutive AhR signaling and crosstalk with Src. (1) Binding of various exogenous and endogenous ligands to the cytoplasmic AhR or deletion of the ligand binding domain stimulates translocation to the nucleus where the AhR/ARNT heterodimer forms. The AhR-ARNT dimer binds to a cognate xenobiotic response element (XRE) to induce transcription of genes important in a wide range of biological processes. (2). AhR forms aprotein complex with Src and regulates Src activity by phosphorylating Src at Tyr416 and dephosphorylating Src at Tyr527. (3) Phosphorylation of AR protein by non-receptor tyrosine kinases Src.