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. 2017 Aug 29;2(8):5122–5127. doi: 10.1021/acsomega.7b00970

Scheme 2. Preparation of Bis(2′,3′-O-methyleneadenosin-5′-yl)-H-phosphonate (1h) and 2′,3′-O-Methyleneadenosin-5′-yl-H-phosphonate (3h).

Scheme 2

Reagents and conditions: (a) diphenyl phosphite, pyridine, 25 °C; (b) 1. Diphenyl phosphite, pyridine, 25 °C and 2. H2O, Et3N, pyridine, 25 °C.