Figure 6.

Results of YSK-LNPs formed in the iLiNP device and in vivo experiments. (A) Comparison of the YSK-LNP sizes produced by the conventional vortex method, the microfluidic device without mixer structures, and the iLiNP device. The error bars represent the standard deviation calculated from repeating each YSK-LNP formation experiment at least three times. (B) FVII gene-silencing activity of siFVII-loaded YSK-LNPs at different doses to mice. N.C.: negative control. (C) Confocal microscopic images of the mice liver tissues. Blood vessels, LNPs, and siRNAs were visualized as green, cyan, and red, respectively.