Table 4 –

First time point features of patients meeting possible or probable bvFTD criteria who had stable diagnoses or change in diagnosis

	Total n	Stable diagnosis	Changed diagnosis	p value
Age at presentation	89	62.1 (7.6)	61.9 (8.8)	0.92
Gender (M/F)	89	40/26	17/6	0.37
MMSE	87	24.3 (5.1)	26.8 (3.1)	0.04*
CDR total	87	1.3 (0.6)	0.8 (0.4)	< .001*
CDR sum of boxes	87	6.9 (2.7)	4.4 (2.1)	< .001*
FTDC criteria core features
Disinhibition	89	92.40%	91.30%	1
Apathy	89	90.90%	65.20%	0.01*
Loss of sympathy/empathy	89	78.80%	56.50%	0.07
Compulsive behavior	89	80.30%	73.90%	0.73
Hyperorality	88	80.00%	73.90%	0.75
Neuropsychological profile	87	53.10%	47.80%	0.85
Additional diagnoses listed
Secondary (contributing) factors		24.2%	56.5%	0.01*
Secondary (alternative) diagnoses		21.2%	34.8%	0.31
NPI (frequency x severity scores)
Delusions	85	1.5 (2.7)	1.8 (3.4)	0.67
Hallucinations	85	0.5 (1.8)	0 (0)	0.21
Agitation/Aggression	83	2.5 (3.4)	3.2 (3.4)	0.4
Depression/Dysphoria	85	1.1 (2.2)	2.4 (3.1)	0.04*
Anxiety	84	2.1 (3.1)	3.5 (3.8)	0.11
Elation/Euphoria	84	3.9 (3.9)	3.3 (3.6)	0.51
Apathy/Indifference	83	8.2 (2.9)	6.6 (4.3)	0.06
Disinhibition	83	7.3 (3.7)	4.7 (3.6)	0.006*
Irritability/Lability	83	2.9 (3.7)	3.8 (4.6)	0.36
Motor Disturbance	83	7.2 (4.2)	4.2 (4)	0.007*
Nighttime Behaviors	84	2.8 (3.4)	2.9 (4.2)	0.9
Appetite/Eating	83	7.4 (3.1)	4.7 (4.8)	0.004*
NPI Total	79	47.8 (19.2)	42.8 (24.3)	0.36
Neuropsychological testing
CVLT-SF long delay free recall	81	3.5 (2.7)	3 (3.1)	0.49
Modified Trails Time	80	77.1 (42)	65.5 (36.7)	0.26
Design Fluency Correct Responses	79	5.2 (3.9)	7.2 (3.7)	0.05
Design Fluency Repetitions	79	5 (5.8)	2.3 (3.7)	0.05
Benson figure copy	85	14.6 (1.9)	15 (2.1)	0.4
D-Word Fluency	84	8 (4.8)	10.9 (5.3)	0.02*