Table 2.
Distribution of hypertensive disorders of pregnancy (HDP) events and age-related macular degeneration (AMD) outcomes.
| Events and outcomes | HDP exposed women | 2:1 unexposed women | |||
|---|---|---|---|---|---|
| N | % | N | % | P* | |
| Total number of HDP events: | 36,182 | 100.0 | — | – | |
| Eclampsia | 849 | 2.3 | — | – | |
| HELLP | 369 | 1.0 | — | – | |
| Preeclampsia | 16,053 | 44.4 | — | – | |
| Pregnancy-induced hypertension (GHTN) | 18,911 | 52.3 | — | – | |
| Total number of births: | 31,454 | 100.0 | 62,908 | 100.0 | |
| Single HDP event at birth: | 26,842 | 85.3 | — | – | |
| Eclampsia | 781 | 2.5 | — | – | |
| HELLP | 144 | 0.5 | — | – | |
| Preeclampsia | 11,555 | 36.7 | — | – | |
| GHTN | 14,362 | 45.7 | — | – | |
| Multiple HDP events at birth: | 4,612 | 14.7 | — | – | |
| Eclampsia and: HELLP or preeclampsia | 32 | 0.1 | — | – | |
| Eclampsia and GHTN | 34 | 0.1 | — | – | |
| HELLP and: preeclampsia or GHTN | 104 | 0.3 | — | – | |
| Preeclampsia and GHTN | 4,326 | 13.8 | — | – | |
| Total number of AMD outcomes: | 681 | 100.0 | 1,355 | 100.0 | |
| CNV AMD | 158 | 23.2 | 284 | 21.0 | |
| Non-CNV AMD | 310 | 45.5 | 650 | 48.0 | |
| Unspecified if CNV or non-CNV | 213 | 31.3 | 421 | 31.1 | 0.44 |
| Age at index CNV AMD (mean, ±SD) | 74.7 | 8.01 | 75.8 | 7.65 | 0.28 |
| Under 70 years | 41 | 25.9 | 51 | 18.0 | |
| 70 years or older | 117 | 74.1 | 233 | 82.0 | 0.005 |
| Age at index non-CNV AMD (mean, ±SD) | 75.3 | 7.39 | 75.5 | 7.53 | 0.69 |
| Under 70 years | 70 | 22.6 | 130 | 20.0 | |
| 70 years or older | 240 | 77.4 | 520 | 80.0 | 0.40 |
| Years from HDP to CNV AMD (mean, ±SD) | 45.7 | 8.76 | 46.8 | 8.52 | 0.22 |
ABBREVIATIONS: HELLP, hemolysis, elevated liver enzymes, and low platelets. GHTN, gestational hypertension. CNV, Choroidal neovascularization.
*
Mantel-Haenszel chi-square test of association, categorical variables; paired t-test, continuous variables.