TABLE 3.

The associations of demographic and clinical characteristics with plasma endothelin-1 (ET-1) concentrations by cocaine use status, robust regression

	Univariate model				Final multivariate model
Characteristics	Estimate	SE	P value		Estimate	SE	P value
	All
Age	0.012	0.003	<0.001		0.012	0.003	<0.001
Current cigarette smoking	0.317	0.060	<0.001		0.324	0.059	<0.001
Years of cigarette smoking	0.012	0.002	<0.001
Years of alcohol use	0.005	0.002	0.040
Long-term cocaine use	0.239	0.062	<0.001
Body mass index (BMI, kg/m2)	−0.007	0.005	0.149
Duration of PI therapy (months)	0.001	0.001	0.026
Duration of NRTI therapy (months)	0.002	0.001	0.009
Duration of NNRTI therapy (months)	0.002	0.001	0.068
	Cocaine use
Age	0.017	0.006	0.003		0.024	0.006	<0.001
Current cigarette smoking	0.275	0.089	0.002		0.331	0.086	<0.001
Years of cigarette smoking	0.011	0.003	0.000
Total cholesterol (mg/dL)	−0.002	0.001	0.062		−0.002	0.001	0.049
Duration of PI therapy (months)	0.001	0.001	0.081
Duration of NRTI therapy (months)	0.002	0.001	0.027
Duration of NNRTI therapy (months)	0.004	0.001	0.003		0.003	0.001	0.004
	Cocaine non-use
Current cigarette smoking	0.310	0.080	<0.001		0.609	0.164	<0.001
Years of cigarette smoking	0.006	0.003	0.058
Systolic BP (mm Hg)	−0.004	0.002	0.095
HDL–C (mg/dL)	−0.005	0.002	0.054
CD4 count at baseline (cells/mm3)	−0.0006	0.0003	0.065		−0.001	0.000	0.008