. 2018 May 25;3(5):5643–5653. doi: 10.1021/acsomega.8b00805

Table 3. Optimization of Conditions for the Reaction of 4a and 2a^a.

entry	Cu catalyst	base	solvent	yield^b (%)
1^c^,^d	CuI	Cs₂CO₃	DMF	43
2^d	CuI	Cs₂CO₃	DMF	47
3	CuI	Cs₂CO₃	DMF	63
4	CuBr	Cs₂CO₃	DMF	59
5	CuCl	Cs₂CO₃	DMF	51
6	Cu powder	Cs₂CO₃	DMF	28
7	CuI	K₂CO₃	DMF	81
8	CuI	K₃PO₄	DMF	77
9	CuI	NaO^tBu	DMF	69
10	CuI	K₂CO₃	DMSO	51
11	CuI	K₂CO₃	1,4-dioxane	42

Reaction conditions: 4a (0.3 mmol), 2a (0.6 mmol), Cu catalyst (0.06 mmol), base (0.9 mmol), solvent (3 mL), microwave irradiation (initial power, 100 W), 130 °C, 1 h, unless otherwise stated.

Isolated yield.

In the presence of l-proline (0.09 mmol).

CuI (0.03 mmol).

Table 3. Optimization of Conditions for the Reaction of 4a and 2aa.

Table 3. Optimization of Conditions for the Reaction of 4a and 2a^a.