Fig. 6.

C57/B6 mice were fed with a high fat diet for three months and received binge alcohol to induce liver injury. A circulating concentration of transaminases and triglycerides were increased by HFD and alcohol. B HFD and multiple alcohol binges caused differential changes in gene expression in liver and adipose tissue. CXCL11 was predominantly increased in adipose tissue. 3 T3-derived adipocytes were incubated with ethanol. C Increased gene expression of CXCL11 was seen at physiological doses at ethanol. D triglyceride loading of adipocytes was reduced by ethanol in a dose-dependent manner illustrated with Oil-red O staining. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)