Table 1.

Cox univariable and multivariable analyses under the condition of overall survival probability in association with miR-25/IMPA2 mRNA expression levels and pathological stage derived TCGA cohort with clear-cell renal cell carcinoma.

Overall survival (n = 237)
Variables	Univariable (HR, 95%CI)	P	Multivariable (HR, 95%CI)	P
Age
<67	1	NA	1	NA
≥67	1.47 (0.97–2.23)	0.069	1.43 (0.92–2.19)	0.111
Gender
Female	1	NA	1	NA
Male	1.05 (0.69–1.60)	0.827	1.74 (1.06–2.86)	0.029
pT
T1-T2	1	NA	1	NA
T3-T4	2.74 (1.79–4.17)	<0.001	1.08 (0.46–2.55)	0.853
pN
N0	1	NA	1	NA
N1	2.95 (1.52–5.71)	<0.001	1.33 (0.65–2.71)	0.437
pM
M0	1	NA	1	NA
M1	3.81 (2.46–5.92)	<0.001	2.55 (1.50–4.32)	<0.001
Stage
I-II	1	NA	1	NA
III-IV	3.10 (1.99–4.81)	<0.001	1.53 (0.59–3.95)	0.377
Grade
I-II	1	NA	1	NA
III-IV	2.47 (1.56–3.92)	<0.001	1.74 (1.06–2.86)	0.029
miR-25/IMPA2 levels
Low/high	1	NA	1	NA
High/low	3.22 (1.75–5.95)	<0.001	2.43 (1.21–4.91)	0.013

HR and CI denote hazard ratio and confident interval, respectively.