Table 3.
Intraoperative fluids and vasoactive medications in undergoing major liver resection with and without restrictive fluid therapy. Data presented as number (proportion). Effect size reported as odds ratio (95% Confidence Interval).
| Restrict group (n = 24) | Conventional care group (n = 24) | Effect size (CI) | p value | |
|---|---|---|---|---|
| Total fluid intraoperatively (mL) (including colloids, crystalloids and blood) | 2000 (1050:2449) | 2000 (1500:2875) | −388 (−958:183)a | 0.18 |
| Median fluid infusion rate (mL/kg/hr) | 4.3 (2.6:5.8) | 6.0 (4.2:7.6) | 1.69 (0.13: 3.25)a | 0.03 |
| Total fluid balance (mL) | 808 (571:1565) | 1345 (900:1983) | 537 (26:1071)a | 0.05 |
| Urine output (mL) | 290 (163:563) | 280 (173:304) | −131.5 (−276:12.9)a | 0.07 |
| Crystalloid therapy | ||||
| No of patients | 24 (100%) | 24 (100%) | >0.99 | |
| Total volume (mL) | 1875 (1000:2000) | 2000 (1125:2000) |
0.25 | |
| Colloid therapy (excluding blood) | ||||
| No of patients | 15 (62.5%) | >0.99 | ||
| Total volume (mL) | 200 (500:700) | 14 (58%) | 0.44 | |
| 20% albumen | 200 (175:550) | |||
| No of patients | 7 (29%) | >0.99 | ||
| Total volume (mL) | 200 (200:200) | 8 (33%) | >0.99 | |
| 4% albumen | 200 (125:200) | |||
| No of patients | 6 (25%) | 0.75 | ||
| Total volume (mL) | 500 (500:1000) | 8 (33%) 500 (500:875) |
0.66 | |
| Blood transfusion | ||||
| No of patients | 2 (8%) | |||
| Total volume (mL) | 356 (248:465) | 1 (4%) | >0.99 | |
| 465 (465:465) | Not estimable | |||
| Any vasoactive/inotrope | 23 (96%) | 22 (92%) | 2.09 (0.18:24.7)b | 0.55 |
| Metaraminol | 4 (25%) | 11 (46%) | 0.06 | |
| Norepinephrine or phenylephrine | 17 (71%) | 13 (53%) | 0.37 | |
| Ephedrine | 3 (12.5%) | 6 (25%) | 0.46 | |
| Dopamine/dobutamine | 7 (29%) | 3 (12.5%) | 0.29 | |
| Metoprolol/esmolol | 1 (4%) | 2 (8%) | >0.99 | |
a
Incidence rate ratio.
b
Odds ratio.