Table 2.
Cox regression analyses of overall and progression-free survivals in the training data set.
| Univariate analysis | Progression-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | ||||
| <65 years | 1 | 1 | ||
| ≥65 years | 0.6 (0.33–1.11) | 0.102 | 0.55 (0.28–1.08) | 0.081 |
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 0.85 (0.44–1.62) | 0.617 | 0.77 (0.38–1.56) | 0.464 |
| KPS | ||||
| 90 | 1 | 1 | ||
| 80 | 0.97 (0.55–1.7) | 0.903 | 1 (0.54–1.86) | 0.989 |
| 70 | 5.21 (1.16–23.47) | 0.032 | 3.38 (0.77–14.88) | 0.107 |
| Location | ||||
| Upper | 1 | 1 | ||
| Middle | 0.89 (0.5–1.57) | 0.679 | 0.82 (0.44–1.52) | 0.527 |
| Lower | 2.87 (0.98–8.37) | 0.054 | 1.15 (0.34–3.9) | 0.825 |
| Length | ||||
| <5 cm | 1 | 1 | ||
| ≥5 cm | 1.31 (0.75–2.26) | 0.342 | 1.51 (0.83–2.76) | 0.178 |
| Clinical T stage | ||||
| T2 | 1 | 1 | ||
| T3 | 1.61 (0.67–3.88) | 0.284 | 1.44 (0.55–3.76) | 0.455 |
| T4 | 1.89 (0.72–4.9) | 0.194 | 1.81 (0.64–5.12) | 0.262 |
| TNM sixth edition | ||||
| IIb | 1 | 1 | ||
| III | 1.41 (0.51–3.93) | 0.509 | 1.66 (0.51–5.38) | 0.398 |
| Response | ||||
| CR | 1 | 1 | ||
| PR | 1.08 (0.5–2.35) | 0.837 | 1.46 (0.56–3.78) | 0.435 |
| SD | 2.72 (1.07–6.92) | 0.035 | 4.21 (1.42–12.46) | 0.01 |
| Compactness | ||||
| Low risk | 1 | 1 | ||
| Moderate risk | 1.61 (0.83–3.13) | 0.156 | 2.02 (0.98–4.16) | 0.056 |
| High risk | 3.69 (1.87–7.28) | <0.001 | 2.87 (1.38–5.97) | 0.005 |
| Multivariate analysis | ||||
| Age | ||||
| <65 years | 1 | 1 | ||
| ≥65 years | 0.41 (0.19–0.87) | 0.02 | 0.48 (0.21–1.07) | 0.072 |
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 1.37 (0.65–2.91) | 0.409 | 1.31 (0.57–3.01) | 0.521 |
| KPS | ||||
| 90 | 1 | 1 | ||
| 80 | 0.86 (0.45–1.62) | 0.635 | 1.05 (0.53–2.07) | 0.891 |
| 70 | 4.11 (0.82–20.61) | 0.086 | 2.58 (0.5–13.46) | 0.26 |
| Location | ||||
| Upper | 1 | 1 | ||
| Middle | 1.17 (0.63–2.17) | 0.615 | 1.1 (0.57–2.12) | 0.781 |
| Lower | 5.21 (1.22–22.31) | 0.026 | 0.95 (0.16–5.54) | 0.952 |
| Length | ||||
| <5 cm | 1 | 1 | ||
| ≥5 cm | 1.49 (0.79–2.81) | 0.215 | 1.54 (0.78–3.05) | 0.212 |
| TNM sixth edition | ||||
| IIb | 1 | 1 | ||
| III | 1.75 (0.56–5.51) | 0.337 | 1.71 (0.47–6.28) | 0.418 |
| Response | ||||
| CR | 1 | 1 | ||
| PR | 1.23 (0.54–2.8) | 0.615 | 1.48 (0.53–4.13) | 0.458 |
| SD | 4.4 (1.56–12.43) | 0.005 | 6.65 (2.06–21.49) | 0.002 |
| Compactness | ||||
| Low risk | 1 | 1 | ||
| Moderate risk | 2.48 (1.21–5.09) | 0.013 | 2.73 (1.27–5.87) | 0.01 |
| High risk | 3.37 (1.55–7.31) | 0.002 | 3.13 (1.25–7.83) | 0.015 |
HR: hazard ratio, CI: confidence interval, KPS: Karnofsky Performance Score, CR: complete response, PR: partial response, SD: stable disease.