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. 2019 Jul 19;9:10484. doi: 10.1038/s41598-019-46990-3

Figure 1.

Figure 1

Serum adiponectin and leptin concentrations at the diagnosis of AE-IPF. Serum adiponectin and leptin levels were evaluated in 39 episodes of AE-IPF. Median adiponectin and leptin concentrations at AE-IPF were 7892 ng/mL and 8.72 ng/mL, respectively. Serum adiponectin levels tended to be higher than those at the initial diagnosis of IPF (a; p = 0.148). Serum leptin levels at AE-IPF were significantly higher than those at the initial diagnosis of IPF (n = 16) and those of healthy controls (n = 48) (b; p = 0.021 and p < 0.0001, respectively). Regarding serial change in identical patients (n = 16), both adiponectin and leptin levels significantly increased at AE-IPF compared with those at initial IPF diagnosis (c, p = 0.007; d, p = 0.027, respectively).