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. 2019 Jul 19;9:10484. doi: 10.1038/s41598-019-46990-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of serum A/L ratio on survival. Among 32 patients with AE-IPF, Kaplan-Meier survival curves from the first AE-IPF onset are shown. When patients were divided into two groups based on median value of each adipokine, the 12-month survival rates were not significantly different between patients with higher and lower adiponectin or leptin (a; adiponectin, log-rank test, p = 0.120 and b; leptin, log-rank test, p = 0.850, respectively). The 12-month survival rate was significantly lower in patients with higher A/L ratio (≥905) than in those with lower A/L ratio (c, log-rank test, p = 0.026).