Table 2.
Multivariate Cox Proportional Hazards models of survival adjusted for age.
| Variable | Hazard Ratio | 95% CI | p Value | |
|---|---|---|---|---|
| lower | upper | |||
| Sex, male | 0.231 | 0.047 | 1.125 | ns. |
| Smoking pack years | 0.985 | 0.967 | 1.004 | ns. |
| Minimum SpO2 in 6MWT before AE*, % | 0.932 | 0.866 | 1.003 | ns. |
| JRS severity grade before AE* | 1.610 | 1.023 | 1.535 | 0.040 |
| Preceding oxygen therapy, + | 2.628 | 1.072 | 6.440 | 0.035 |
| Serum adiponectin, ng/mL | 1.000 | 1.000 | 1.000 | ns. |
| Serum leptin, ng/mL | 0.927 | 0.855 | 1.005 | ns. |
| Adiponectin/leptin ratio | 1.000 | 1.000 | 1.000 | 0.012 |
| Adiponectin/leptin ratio, ≥905 | 2.600 | 1.031 | 6.558 | 0.042 |
| Peripheral blood neutrophils at AE, /μL | 1.000 | 1.000 | 1.000 | 0.020 |
| Serum KL-6 at AE, U/mL | 1.000 | 0.999 | 1.000 | ns. |
| P/F ratio at AE | 0.996 | 0.992 | 1.001 | ns. |
| Period from admission to the beginning of AE treatment, days | 1.125 | 1.008 | 1.255 | 0.035 |
*Pulmonary function tests, severity scores, HRCT, and serum markers were evaluated within 12 months before AE-IPF.
Abbreviations; SpO2: partial oxygen saturation, 6MWT: 6-minute walk test, AE: acute exacerbation, JRS: Japanese respiratory society, KL-6: Krebs von den Lungen-6, P/F: PaO2/FiO2, ns.: not significant.