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. 2019 Jul 19;9:10501. doi: 10.1038/s41598-019-46887-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of original and cleaned post-treatment (T1) models superimposed on the three reference areas used in the study. As shown in the respective colour maps, Patient 4 represents a case with few artifacts in the superimposition reference areas, where the artifact removal already exerted an effect on the superimposition of the original with the subsequent cleaned model. Patient 5 represents a case with more artifacts, and these exerted a greater effect on the superimposition. This differential effect, depending on the amount of artifacts, primarily existed for areas A and B, but not for C, which was the largest one. Superimpositions were performed with setting 1, at M1 (measurement time point 1).