Table 2.
Univariate and multivariate Cox models for metabolite concentrations demonstrating their ability to predict overall survival of paediatric brain tumour patients.
| Variable | Univariate analysis | Multivariate analyses | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | Corrected P-value | Glutamine model | Total lipids model | |||
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Gln | 0.52 (0.31, 0.87) | 0.041 | 0.42 (0.21–0.85) | 0.015 | — | — |
| Total lipids | 2.02 (1.53, 2.66) | 2.48 × 10−4 | — | — | 1.91 (1.35, 2.68) | 2.15 × 10−4 |
| Diagnosis | 4.58 × 10−4 | |||||
| PA | Reference | — | Ref | — | Ref | — |
| AA | 13.03 (2.62, 64.65) | 0.0017 | 9.93(2.99, 49.59) | 0.005 | 15.80 (3.16, 79.16) | 7.86 × 10−4 |
| ACPP | 9.27 (0.95, 90.57) | 0.056 | 3.41 (0.32, 36.58) | 0.31 | 8.08 (0.82, 79.10) | 0.073 |
| ATRT | 17.11 (3.80, 76.95) | 2.1 × 10−4 | 8.63 (1.75, 42.61) | 0.0081 | 11.69 (2.38, 57.53) | 0.0025 |
| CPC | 35.46 (3.52, 357.31) | 0.0025 | 9.48 (0.79, 113.46) | 0.076 | 10.39 (0.96, 112.40) | 0.054 |
| EP | 2.55 (0.51, 12.63) | 0.25 | 1.34 (0.25, 7.09) | 0.73 | 2.61 (0.53, 12.98) | 0.24 |
| GBM | 31.72 (7.77, 129.45) | 1.5 × 10−6 | 32.73 (7.86, 136.23) | 1.64 × 10−6 | 22.29 (5.32, 93.31) | 2.14 × 10−5 |
| MB | 5.91 (1.68, 20.76) | 0.0056 | 2.45 (0.61, 9.89) | 0.21 | 5.71 (1.62, 20.11) | 0.0066 |
| PNET | 14.12 (1.44, 138.02) | 0.023 | 6.03 (0.58, 63.08) | 0.13 | 21.69 (2.15, 218.62) | 0.009 |
As no deaths were recorded for patients diagnosed with GG, AB, CPP or the unclassified glial tumour, these entries have been excluded from this table.