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. 2019 Jul 19;9:10533. doi: 10.1038/s41598-019-46981-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted association of dys-regulated LncRNAs to altered mRNA expression in cocaine and Tat treated HPASMCs. (A) Table lists microarray details of selected top lncRNA/mRNA predicted associations. (B) KEGG pathway enrichment for mRNAs associated to lncRNAs based on genomic proximity (<300kbp). (C,D) Quantitative RT-PCR based validation of selected lncRNA/mRNA pairs from vascular disease and cancer co-expression database (C); and from genomic proximity (D) analysis. p-value ^*<0.05 vs. control (Con), ^##<0.01, ^#<0.05 vs. cocaine(Coc), ^$$<0.01, ^$<0.05 vs. Tat.