Table 4.
List of down-regulated lncRNAs/mRNAs with potential up-regulated miRNA targets in cocaine and Tat treated hyper-proliferative smooth muscle cells.
| LncRNA | Fold change | P-value | miRNA | No. of binding sites on lncRNA | Fold change | P-value |
|---|---|---|---|---|---|---|
| ENST00000596769 | −2.8621 | 0.0043 | hsa-miR-133a-3p | 7 | 1.6677 | 0.0919 |
| hsa-miR-130b-5p | 4 | 1.7023 | 0.0386 | |||
| ENST00000603037 | −1.5199 | 0.0208 | hsa-let-7a-5p | 4 | 2.1128 | 0.0011 |
| TCONS_00014969 | −3.2602 | 0.0194 | hsa-miR-125b-5p | 4 | 1.5854 | 0.0032 |
| ENST00000589511 | −2.6857 | 0.0467 | hsa-miR-125b-5p | 4 | 1.5854 | 0.0032 |
| TCONS_00012168 | −1.6284 | 0.0000 | hsa-miR-130b-5p | 4 | 1.7023 | 0.0386 |
| TCONS_00026830 | −4.1484 | 0.0010 | hsa-let-7a-5p | 3 | 2.1128 | 0.0011 |
| ENST00000412149 | −1.5780 | 0.0134 | hsa-miR-10b-5p | 3 | 1.6354 | 0.0038 |
| hsa-miR-125b-5p | 3 | 1.5854 | 0.0032 | |||
| ENST00000603095 | −1.7070 | 0.0282 | hsa-miR-133a-3p | 3 | 1.6677 | 0.0919 |
| ENST00000596769 | −2.8621 | 0.0043 | hsa-miR-10b-5p | 2 | 1.6354 | 0.0038 |
| TCONS_00026830 | −4.1484 | 0.0010 | hsa-miR-130b-5p | 2 | 1.7023 | 0.0386 |
| ENST00000595853 | −2.6963 | 0.0011 | hsa-miR-130b-5p | 2 | 1.7023 | 0.0386 |
| ENST00000569618 | −2.0383 | 0.0213 | hsa-miR-98-3p | 2 | 1.7129 | 0.0391 |
| ENST00000521148 | −1.5589 | 0.0243 | hsa-miR-10b-5p | 1 | 1.6354 | 0.0038 |
| ENST00000549516 | −2.2653 | 0.0242 | hsa-miR-125b-5p | 1 | 1.5854 | 0.0032 |
| ENST00000518355 | −1.7250 | 0.0039 | hsa-miR-125b-5p | 1 | 1.5854 | 0.0032 |
| ENST00000570084 | −1.8786 | 0.0116 | hsa-miR-130b-5p | 1 | 1.7023 | 0.0386 |
| ENST00000422345 | −2.2413 | 0.0100 | hsa-miR-133a-3p | 1 | 1.6677 | 0.0919 |
| TCONS_00013442 | −1.8486 | 0.0223 | hsa-miR-133a-3p | 1 | 1.6677 | 0.0919 |
| hsa-miR-454-3p | 1 | 2.2159 | 0.0003 | |||
| miRNA | mRNA | |||||
| hsa-let-7a-5p |
AC144568.2, ARHGEF15, ARHGEF39, ATXN1L, CACNG4, CBL, CCL3L1 CXorf36, DRD3, GJB4, HOXC11, IL12RB2, KCTD21, LIMD2, LOR, LRRC10 MS4A7, MYO5B, PADI4, PRLR, PRR18, SALL4, SCN4B, SCYL3, SLC13A3 SPRED3, TBC1D13, TMPPE, TNFSF9, TRIM67, TTC22, ZBTB8B, ZNF835 ZPLD1 |
|||||
| hsa-miR-125b-5p |
ALOX5, ARHGEF39, CCDC169, CCR5, CD69, CTB_54O99, GLB1L2, ITGA7 KCNJ9, KCNK10, KCTD21, LIMD2, MALL, OVOL1, PLD6, PRAMEF18/PRAMEF19 RASD2, RASGRF2, SERPINE3, SHTN1, SLC25A48, ST8SIA4, TTPA, VTCN1 ZBTB8B |
|||||
| hsa-miR-130b-5p |
CCDC170, CCSER1, CEP83, ENDOU, KCNJ13, LHX6, OR2H1, RAET1L, RNF138 SLC26A4, SMOC1, SYN3, ULBP2 |
|||||
| hsa-miR-133a-3p |
ARHGEF39, BMP7, CACNA2D4, CELF6, COL9A2, DAND5, DOLPP1, GLOD5 GZMM, KCNJ9, PIRT, PROK1, PRR30, RASGRF2, SH3GL2, SIGLEC8, SLC7A2 TDRKH, ZNF69 |
|||||
| hsa-miR-454-3p |
CD69, CDK19, ELK3, FAM129C, GRK7, KCNK10, MCHR1, MS4A7, NMUR2 ODF4, PLPPR1, RASGRF2, RD3, RGS7BP, SMOC1, ST8SIA5, ZPLD1 |
|||||
| hsa-miR-10b-5p | ANXA13, AWAT1, CHST9, DAND5, FCMR, IL5RA, LHPP, NPAS3, PLA1A, PRAMEF18/PRAMEF19, SLC6A19, SLC7A2, SYNGR1, ZNF69 | |||||
| hsa-miR-98-3p |
AC144568.2, ALG10B, C20orf197, P2RY13, RAD51B, RNF138, SLC25A31 ST8SIA4, ZC2HC1B |
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