Table 3.
Exact replication of established T2D loci in 5231 sub-Saharan Africans
| SNP | CHR | BP | EA | NEA | EAF | β | SE | p Value | Locus |
|---|---|---|---|---|---|---|---|---|---|
| rs7903146 | 10 | 114758349 | T | C | 0.331 | 0.351 | 0.049 | 7.29E−13 | TCF7L2 |
| rs10998572 | 10 | 70859204 | A | C | 0.055 | −0.245 | 0.105 | 1.933E−02 | VPS26A |
| rs231360 | 11 | 2692249 | T | C | 0.620 | 0.145 | 0.048 | 2.378E−03 | KCNQ1 |
| rs441613 | 11 | 2910191 | C | T | 0.605 | 0.115 | 0.047 | 1.451E−02 | KCNQ1 |
| rs2258238 | 12 | 66221060 | T | A | 0.367 | −0.101 | 0.048 | 3.738E−02 | HMGA2 |
| rs12595616 | 15 | 91563513 | C | T | 0.852 | −0.227 | 0.066 | 5.438E−04 | PRC1 |
| rs1558902 | 16 | 53803574 | A | T | 0.050 | 0.245 | 0.105 | 1.973E−02 | FTO |
| rs2925979 | 16 | 81534790 | C | T | 0.676 | −0.107 | 0.049 | 2.950E−02 | CMIP |
| rs7224685 | 17 | 4014384 | T | G | 0.435 | 0.147 | 0.046 | 1.402E−03 | ZZEF1 |
| rs13342692 | 17 | 6946287 | C | T | 0.393 | 0.145 | 0.047 | 2.009E−03 | SLC16A11/A13 |
| rs7234111 | 18 | 7067652 | C | T | 0.584 | 0.0948 | 0.047 | 4.433E−02 | LAMA1 |
| rs4402960 | 3 | 185511687 | T | G | 0.570 | 0.116 | 0.047 | 1.369E−02 | IGF2BP2 |
| rs1182436 | 7 | 157027753 | C | T | 0.326 | 0.104 | 0.050 | 3.779E−02 | MNX1 |
| rs3802177 | 8 | 118185025 | A | G | 0.038 | −0.311 | 0.118 | 8.654E−03 | SLC30A8 |
| rs10757282 | 9 | 22133984 | C | T | 0.207 | 0.149 | 0.056 | 7.372E−03 | CDKN2A/B |
| rs1575972 | 9 | 22301092 | A | T | 0.320 | −0.196 | 0.049 | 6.47E−05 | DMRTA1 |
| rs10758593 | 9 | 4292083 | A | G | 0.512 | 0.117 | 0.046 | 1.126E−02 | GLIS3 |
| rs3842770 | 11 | 2178670 | A | G | 0.291 | 0.124 | 0.053 | 1.867E−02 | INS-IGF2 |
EA effect allele, NEAnoneffect allele