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. 2019 Jul 19;9:10503. doi: 10.1038/s41598-019-46385-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selected phosphorylation motifs found in this study. (a) Known and (b) unreported phosphorylation motifs extracted by motif-x with a significant score from the in vitro kinase substrates (see Supplementary Table S3 for all motifs covering 306 kinases, 12 families and 5 clusters). (c) Amino acid frequency in specific substrates for wild-type or Y1235D mutant of MET. These logos were generated by using Weblogo⁷⁴. (d,e) Correlation between phosphorylation motif and phosphorylation stoichiometry. Phosphorylation stoichiometry was obtained from the peak area ratio of the corresponding dephosphorylated sample after in vitro kinase reaction with (d) p38γ and (e) EPHA1 (as described in Supplementary Information).