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. 2019 Jul 19;9:10503. doi: 10.1038/s41598-019-46385-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Classification of serine/threonine kinases based on in vitro substrates. A phylogenic kinome tree based on the cluster analysis. The background color of the kinase name indicates the reported kinase group² (see Supplementary Fig. S4 for TKs data). The threonine-specific kinases, i.e., those for which more than 50% of the substrate sites contain threonine, are indicated by asterisks (*). The kinases indicated by sharps (#) also phosphorylated tyrosine residues at a rate of more than 20% of their total substrates. The bars indicate (a) the number of serines/threonines/tyrosines or (b) the ratio of multiply phosphorylated peptides identified in each in vitro kinase profiling. The maximum ratio of multiply phosphorylated peptides (observed in TTBK1) is 0.39.