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. 2019 Jul 19;10:3211. doi: 10.1038/s41467-019-11193-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — In vivo antitumor efficacy of prodrug nanoassemblies. (a) Tumor volume. (b) Tumor burden. (c) Images of tumors. (d) Body weight changes. Data are presented as mean ± SD (five independent experiments). *P < 0.05, **P < 0.01 by two-tailed Student’s t test. (e) Hepatorenal function parameters. Data are presented as mean ± SD (three independent experiments). AST: aspartate aminotransferase (U L⁻¹); ALT: alanine aminotransferase (U L⁻¹), BUN: blood urea nitrogen (mmol L⁻¹), CREA: creatinine (μmol L⁻¹)