Table 3.
Longitudinal changes in LED across time in PD patients.
| Estimated slope (standard error) | ||||||
|---|---|---|---|---|---|---|
| Low Eratio group | p value | High Eratio group | p value | Difference | p value | |
| Δ LED | 10.9394 (0.8114) | <0.001 | 7.0584 (0.8880) | <0.001 | 3.8810 (1.2010) | 0.001 |
The estimate (β) is the change in LED per month (Δ LED), i.e., positive value indicates the dose-up of PD medications. The effect of the PD subgroup (low estrogen exposure ratio group versus high estrogen exposure ratio group) on the change in LED across time was tested using the time x PD subgroup interaction term, and the low estrogen exposure ratio group exhibited a faster rate of dose-up of PD medications than the high estrogen exposure ratio group. Abbreviations: LED, levodopa-equivalent dose; PD, Parkinson’s disease; Eratio, Estrogen exposure ratio.