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. 2019 Jul 19;10:3229. doi: 10.1038/s41467-019-11148-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Inflammation triggers transcriptomic changes in monocyte immediately upon entry into the small intestine. a Heat map demonstrating gene expression profiles of adoptively transferred CD11b⁺CD11c^lo/intCD64⁺ (MNP^CD64+) cells recovered small intestinal lamina propria (siLP) of non-manipulated and manipulated recipients at day 1, 2, and 5 after transfer. b Principal component analysis (PCA) representing transcriptomic profiles of donor BM monocytes before transfer and adoptively transferred MNP^CD64+ cells recovered from siLP of non-manipulated and manipulated recipients at day 1, 2, and 5 post-transfer. c–e Heat map showing hierarchal clustering of gene expression profiles of donor MNP^CD64+ cells recovered from the siLP at day 1 (c), day 2 (d), and day 5 (e) after transfer comparing non-manipulated and manipulated recipients. Transcriptomic analysis was performed by nanostring nCounter analysis and differentially expressed genes were determined by Qlucore Omics explorer with a statistical significance p-value of 0.05. Data were pooled from 2–3 independent experiments with a total of 2–5 mice as indicated in each section of the figure