Fig. 5.

LAIR1 transcript levels stratified according to genotypes/haplotypes upon enrolment.

Data are presented as box-plots (fold-change) where the box represents the interquartile range, the line through the box is the median, and whiskers show the 10th and 90th percentiles. Kruskal-Wallis tests were used to compare transcript levels across the clinical groups, and Mann-Whitney U tests were used to compare two groups.

(a) LAIR1 transcript levels were stratified according to genotypes. At 16231, LAIR1 transcript levels differed across the genotypes. Compared to both the CC and CA genotypes, carriers of the AA genotype had lower transcriptional expression. At 18835, LAIR1 transcript levels differed across the genotypes with GA carriers having the highest transcript levels.

(b) LAIR1 transcript levels stratified into non-carriers (0 copies) vs. carriers (1 or 2 copies) of the haplotypes. Inheritance of the ‘protective’ CG haplotype was associated with higher LAIR1 expression. Conversely, carriers of the ‘susceptible’ AG haplotype had marginally lower transcript levels than non-carriers.

(c) LAIR1 transcript levels stratified into 0, 1, or 2 copies of the haplotypes. Carriers of 1 copy of the ‘protective’ CG haplotype had elevated transcript levels relative to non-carriers and carriers of 2 copies. Inheritance of 2 copies of the ‘susceptible’ AG haplotype was associated with marginally lower transcript levels than non-carriers and carriers of 1 copy of the haplotype.