Table 2.
Distribution of LAIR1 genotypes and haplotypes.
| Genotypes/Haplotypes | Aparasitemic | Non-SMA Hb ≥ 5.0 g/dL | SMA Hb < 5.0 g/dL | P | Total |
|---|---|---|---|---|---|
| 16231C>A | |||||
| Sample size (n) | n = 292 | n = 976 | n = 233 | n = 1501 | |
| CC, n (%) | 134 (45.90) | 417 (42.70) | 86 (36.90) | 0.037 | 637 (42.44) |
| CA, n (%) | 120 (41.10) | 432 (44.30) | 100 (42.90) | 652 (43.44) | |
| AA, n (%) | 38 (13.00) | 127 (13.00) | 47 (20.20) | 212 (14.12) | |
| 18835G>A | |||||
| n = 292 | n = 968 | n = 232 | n = 1492 | ||
| GG, n (%) | 99 (33.90) | 315 (32.50) | 95 (40.90) | 0.007† | 509 (34.12) |
| GA, n (%) | 109 (37.30) | 439 (45.40) | 84 (36.20) | 632 (42.36) | |
| AA, n (%) | 84 (28.80) | 214 (22.10) | 53 (22.80) | 351 (23.53) | |
| 16231C>A/18835G>A | |||||
| Sample size (n) | n = 292 | n = 986 | n = 234 | n = 1512 | |
| Non-CG | 102 (34.90) | 291 (29.50) | 84 (35.90) | 0.157 | 477 (31.55) |
| CG (1 copy) | 127 (43.50) | 489 (49.60) | 101 (43.20) | 717 (47.542) | |
| CG (2 copies) | 63 (21.60) | 206 (20.90) | 49 (20.90) | 318 (21.03) | |
| Non-CA | 186 (63.70) | 662 (67.10) | 172 (73.50) | 0.047 | 1020 (67.46) |
| CA (1 copy) | 77 (26.40) | 263 (26.60) | 49 (20.90) | 389 (25.73) | |
| CA (2 copies) | 29 (9.90) | 61 (6.20) | 13 (5.60) | 103 (6.81) | |
| Non-AG | 245 (83.90) | 820 (83.20) | 174 (74.40) | <0.001† | 1239 (81.94) |
| AG (1 copy) | 40 (13.70) | 144 (14.60) | 41 (17.50) | 225 (14.88) | |
| AG (2 copies) | 7 (2.40) | 22 (2.20) | 19 (8.10) | 48 (3.17) | |
| Non-AA | 170 (58.20) | 543 (55.1) | 135 (57.70) | 0.553 | 848 (56.08) |
| AA (1 copy) | 102 (34.90) | 388 (39.40) | 83 (35.50) | 573 (37.90) | |
| AA (2 copies) | 20 (6.80) | 55 (5.60) | 16 (6.80) | 91 (6.02) | |
Data are presented as proportions [n (%)] of genetic variants within the study groups. Study participants were categorized into three groups, aparasitemic, SMA (i.e., Hb < 5.0 g/dL with any density parasitaemia) or non-SMA (Hb ≥ 5.0 g/dL with any density parasitaemia). Statistical significance was determined by the chi-square analysis. Bold indicates P ≤ 0.050. †Significant after Bonferroni correction for multiple comparisons.