Table 3.

Univariate and multivariate logistic regression model analyses of factors affecting 28‐day mortality

Items	Univariate logistic regression		Multivariate logistic regression
	P value	OR (95%CI)	P value	OR (95%CI)
lnc‐ANRIL/miR‐125a axis (high vs low)	<0.001	5.812 (2.456‐13.754)	0.002	8.946 (2.310‐34.654)
Age (≥56 vs < 56 y)	0.166	0.585 (0.274‐1.248)	0.105	0.360 (0.104‐1.238)
Gender (male vs female)	0.888	0.945 (0.429‐2.079)	0.087	0.321 (0.088‐1.179)
BMI (≥22.5 vs < 22.5 kg/m2)	0.903	0.955 (0.451‐2.021)	0.755	1.227 (0.340‐4.435)
Scr (≥1.7 vs < 1.7 mg/dL)	0.016	2.623 (1.195‐5.762)	0.010	9.328 (1.711‐50.839)
Albumin (≥24.7 vs < 24.7 g/L)	0.058	0.475 (0.220‐1.025)	0.373	0.523 (0.126‐2.177)
WBC (≥18.4 vs < 18.4 × 109/L)	0.252	1.556 (0.730‐3.316)	0.186	0.368 (0.083‐1.620)
CRP (≥103.6 vs < 103.6 mg/L)	0.128	1.808 (0.844‐3.872)	0.397	0.487 (0.092‐2.574)
PCT (≥14.2 vs < 14.2 ng/mL)	0.023	2.459 (1.130‐5.351)	0.041	2.475 (1.037‐5.907)
APACHE II score (≥14 vs < 14)	0.031	2.346 (1.079‐5.101)	0.775	0.814 (0.197‐3.354)
SOFA score (≥5 vs < 5)	<0.001	4.818 (2.086‐11.131)	0.048	4.542 (1.014‐20.349)
TNF‐α (≥195.0 vs < 195.0 pg/mL)	0.252	1.556 (0.730‐3.316)	0.702	1.175 (0.514‐2.683)
IL‐6 (≥61.9 vs < 61.9 pg/mL)	0.702	1.158 (0.546‐2.454)	0.653	0.828 (0.364‐1.884)
IL‐8 (≥54.6 vs < 54.6 pg/mL)	<0.001	7.097 (2.911‐17.300)	<0.001	73.388 (8.843‐609.048)
IL‐17 (≥129.4 vs < 129.4 pg/mL)	0.003	3.400 (1.525‐7.578)	0.111	3.569 (0.748‐17.041)

Continuous variables were divided by the median values. P value < 0.05 was considered significant.

Abbreviations: APACHE II, acute physiology and chronic health evaluation II; BMI, body mass index; CI, confidence interval; CRP, C‐reactive protein; IL, interleukin; OR, odds ratio; PCT, procalcitonin; Scr, serum creatinine; SOFA, sequential organ failure assessment; TNF‐α, tumor necrosis factor‐α; WBC, white blood cell.