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. 2019 Jul 19;7(14):e14172. doi: 10.14814/phy2.14172

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Transmission electron microscopy images for human BM‐MSC‐derived EVs repair of proximal tubule and glomerulus damage in Cd‐exposed medaka. Female 0 ppm Cd (A, D, G, J), female 4 ppm Cd (B, E, H, K), female 4 ppm Cd + human BM‐MSC‐derived exosomes (C, F, I, L). Normal proximal tubule (PT) mitochondria (red arrowhead; A, C), normal PT apical membrane vesicle (yellow arrowhead; D, F), normal PT basolateral membrane (red asterisks; G, I), normal glomeruli podocytes (red arrowhead; J, L), damaged PT mitochondria (light blue arrowhead; B), abnormal PT apical vesicles (green arrowhead; E), abnormal PT basolateral (light blue asterisk; H), enlarged podocyte foot process with apoptotic vesicles (light blue arrow; K). The scale bar indicates 600 nm (A, B, C, J, K, L) and 2 μm (D, E, F, G, H, I).