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. 2019 May 17;33(6):e22903. doi: 10.1002/jcla.22903

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© 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Clinical study: A, The expression of IL‐1RA was detected by Western blotting cancerous and paracancerous tissues from eight groups of patients. The results show that the expression of IL‐1RA in esophageal cancer tissues decreased compared to paracancerous tissue. B, Immunohistochemical staining of 76 tumor samples was performed to investigate the expression of IL‐1RA in paracancerous tissues and adjacent tissues and showed that the expression of IL‐1RA was significantly decreased in esophageal cancer patients (P = 0.000). C, The expression of the IL‐1RN gene in esophageal cancer and adjacent tissues was detected by RT‐PCR. The expression of IL‐1RN gene decreased in esophageal cancer tissues (P = 0.0031). D, Kaplan‐Meier survival analysis showing that downregulation of IL‐1RA in the 76 EC samples was associated with poorer overall survival (P = 0.044)