Table 2.

Association between the methylation status of ESRRG promoter and the clinical characteristics of laryngeal squamous cell carcinoma (LSCC) patients

Clinical characteristics	n	MIa of ESRRG (Mean ± SD)%	P value
Age (y)
<60	49	36.79 ± 14.33
≥60	42	35.47 ± 14.93	0.67
Smoking
No	17	33.04 ± 14.00
Yes	74	36.90 ± 14.66	0.33
Differentiation
Well	48	38.85 ± 15.43
Moderate/poor	43	33.21 ± 13.03	0.06
T stage
T1‐2	56	33.06 ± 13.58
T3‐4	35	41.17 ± 14.82	<0.01
N stage
N0	64	34.93 ± 13.37
N1‐2	27	39.15 ± 16.91	0.21
Clinical stage
I, II	45	31.96 ± 11.61
III, IV	46	40.31 ± 16.00	<0.01

^aMI, methylation index, calculated as the mean methylation status of the six CpG sites analyzed.