Fig. 2.
SLC6A4 genotype-dependent differential sensitivity to a 5HT2A antagonist during the HI test. (A) Schematic of the right top quadrant of the home cage, where the HI test takes place. An unfamiliar human stands in front of the cage and stares at the marmoset in the eyes for 2 min. Video and audio tapes were recorded, and behaviors were scored post hoc. Regions closer to the human intruder (corresponding to a less anxious-like state) are shown in blue, and regions further away from the human intruder (corresponding to a more anxious-like state) are shown in red. (B) Response to the human intruder threat after treatment with either vehicle or 5HT2A-specific antagonist M100907 (low [0.1 mg/kg] and high [0.3 mg/kg] doses). Mean ± SEM of average distance from the unfamiliar human is presented for each group in each condition (AC/C/G: vehicle vs. high dose, planned comparison paired 2-tailed t test: P = 0.038).