Fig. 2.

miR-134 knockdown is therapeutic in various in vivo experimental models and species. A - In vivo intracerebroventricular injection of ant-134 in mice mediates a significant knockdown of miR-134 for one month (reproduced with permission from [14]). B - IAKA - intra-amygdala kainic acid (reproduced with permission from [14]): Spectrograms show that status epilepticus is reduced by pre-treatment with ant-134 (left panel). Post-treatment with ant-134 leads to a reduction in spontaneous seizures during the chronic phase of this model (right panel). C - An overview of seizure reduction mediated by ant-134 in different animal models. For pre-treatment studies, we measured the % reduction in total EEG power after KA administration. For post-treatment studies, we measured the % reduction in number of spontaneous seizures in the chronic epilepsy phase of the models. Black bars represent mouse studies and grey bars rat studies. IAKA - intra-amygdala kainic acid; PILO - pilocarpine; PTZ - pentylenetetrazol; PPS - perforant path stimulation.