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. 2019 Jul 19;38:320. doi: 10.1186/s13046-019-1314-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The verification of p-STAT3 transferred by Exo/R and its anti-apoptotic function in RKO/P cells. a, b, c. Representative images of RKO/P treated with 30 μM 5-FU, 10 μM ezatiostat and exosomes for 72 h and statistical analysis of the survival rate. d, e, f. Representative images of RKO/P cells treated with 30 μM 5-FU, 7.5 μM stattic and exosomes for 72 h and statistical analysis of the survival rate. g. RTCA analysis of cell index of RKO/P cells treated with 30 μM 5-FU, Exo/P and Exo/R, DMSO or 5 μM stattic. DP: DMSO + Exo/P, DR: DMSO + Exo/R, SP: stattic + Exo/P, SR: stattic + Exo/R. h. Confocal images of p-STAT3 in RKO/P cells co-cultured with Exo/P or Exo/R in the absence of 5-FU. (scale bar, 25 μm) *P < 0.05, **P < 0.01, ***P < 0.001