Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 19;17:230. doi: 10.1186/s12967-019-1982-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 8 — Possible role of melanoma-derived Exos in regulating the in vitro osteotropism of melanoma cells. a Soluble factors released by the bone fragment up-regulate membrane-CXCR7 levels in osteotropic melanoma cells (LCP), thus stimulating their migration towards the SDF-1 through the CXCR4/CXCR7 signaling activation. By contrast, not-osteotropic cells (SK-Mel28 and WM-266) are refractory to the stimulation from bone-derived soluble factors and SDF-1-mediated chemoattraction cannot be activated. b Exosomes released by osteotropic melanoma cells stimulate not-osteotropic cells to increase membrane levels of CXCR7 resulting in a reprogramming effect on their original chemoattraction toward SDF-1