Table 3.
Summary and subgroup results of the association between common clinicopathological characteristics and BCa
| Analysis specification | No. of studies | Study heterogeneity | HR(95% CI) | P-Value | Analysis specification | No. of studies | Study heterogeneity | HR(95% CI) | P-Value | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| I2 (%) Pheterogeneity | I2 (%) Pheterogeneity | ||||||||||
| Advanced age | LVI | ||||||||||
| Overall | 20 | 68.2 | < 0.001 | 1.01(1.00,1.01) | < 0.001 | Overall | 23 | 68.4 | < 0.001 | 1.36(1.28,1.45) | < 0.001 |
| Geographical region | Geographical region | ||||||||||
| Asia | 8 | 59.3 | 0.016 | 1.01(1.00,1.02) | 0.023 | Asia | 11 | 44.8 | 0.053 | 1.30(1.17,1.43) | < 0.001 |
| non-Asia | 12 | 68.5 | < 0.001 | 1.01(1.00,1.01) | 0.004 | non-Asia | 12 | 74 | < 0.001 | 1.40(1.30,1.52) | < 0.001 |
| Year of publication | Year of publication | ||||||||||
| ≥ 2015 | 13 | 72.4 | < 0.001 | 1.01(1.00,1.01) | 0.037 | ≥ 2015 | 13 | 74.8 | < 0.001 | 1.34(1.22,1.46) | < 0.001 |
| < 2015 | 7 | 39.4 | 0.129 | 1.01(1.00,1.01) | < 0.001 | < 2015 | 10 | 48.9 | 0.040 | 1.40(1.28,1.54) | < 0.001 |
| No. of patients | No. of patients | ||||||||||
| ≥ 500 | 8 | 71.9 | 0.001 | 1.01(1.00,1.01) | 0.002 | ≥ 500 | 10 | 80.6 | < 0.001 | 1.30(1.19,1.42) | < 0.001 |
| < 500 | 12 | 65 | 0.001 | 1.01(1.00,1.02) | 0.074 | < 500 | 13 | 39.1 | 0.073 | 1.44(1.32,1.57) | < 0.001 |
| Median follow-up | Median follow-up | ||||||||||
| ≥ 36 months | 8 | 74.8 | < 0.001 | 1.00(0.99,1.01) | 0.736 | ≥ 36 months | 7 | 72.1 | 0.001 | 1.33(1.19,1.48) | < 0.001 |
| < 36 months | 9 | 35.5 | 0.134 | 1.01(1.00,1.01) | < 0.001 | < 36 months | 10 | 74.3 | < 0.001 | 1.43(1.26,1.62) | < 0.001 |
| Grade | STSM | ||||||||||
| Overall | 17 | 76.9 | < 0.001 | 1.29(1.15,1.45) | < 0.001 | Overall | 15 | 71.7 | < 0.001 | 1.42(1.30,1.56) | < 0.001 |
| Geographical region | Geographical region | ||||||||||
| Asia | 9 | 82.6 | < 0.001 | 1.37(1.12,1.68) | 0.002 | Asia | 7 | 0 | 0.650 | 1.26(1.17,1.36) | < 0.001 |
| non-Asia | 8 | 57.9 | 0.002 | 1.17(1.03,1.34) | 0.020 | non-Asia | 8 | 55.5 | < 0.001 | 1.46(1.27,1.67) | < 0.001 |
| Year of publication | Year of publication | ||||||||||
| ≥ 2015 | 10 | 81.6 | < 0.001 | 1.41(1.17,1.70) | < 0.001 | ≥ 2015 | 12 | 76.1 | < 0.001 | 1.44(1.29,1.61) | < 0.001 |
| < 2015 | 7 | 54.4 | 0.041 | 1.13(0.98,1.31) | 0.085 | < 2015 | 3 | 29.3 | 0.243 | 1.38(1.19,1.60) | < 0.001 |
| No. of patients | No. of patients | ||||||||||
| ≥ 500 | 7 | 71.1 | 0.002 | 1.11(0.99,1.23) | 0.072 | ≥ 500 | 10 | 78.1 | < 0.001 | 1.50(1.32,1.69) | < 0.001 |
| < 500 | 10 | 60.5 | 0.007 | 1.53(1.25,1.87) | < 0.001 | < 500 | 5 | 0 | 0.745 | 1.22(1.13,1.32) | < 0.001 |
| Median follow-up | Median follow-up | ||||||||||
| ≥ 36 months | 6 | 88.3 | < 0.001 | 1.45(1.15,1.84) | 0.002 | ≥ 36 months | 6 | 34.3 | 0.179 | 1.43(1.26,1.62) | < 0.001 |
| < 36 months | 8 | 36 | 0.141 | 1.10(0.98,1.23) | 0.113 | < 36 months | 6 | 75 | 0.001 | 1.53(1.27,1.84) | < 0.001 |
| Stage | CIS | ||||||||||
| Overall | 13 | 92.2 | < 0.001 | 1.60(1.37,1.86) | < 0.001 | Overall | 11 | 78 | < 0.001 | 0.98(0.88,1.10) | 0.753 |
| Geographical region | Geographical region | ||||||||||
| Asia | 7 | 93.1 | < 0.001 | 1.61(1.10,2.63) | 0.013 | Asia | 4 | 91 | < 0.001 | 1.19(0.88,1.61) | 0.251 |
| non-Asia | 5 | 92.5 | < 0.001 | 1.60(1.35,1.90) | < 0.001 | non-Asia | 7 | 43.3 | 0.102 | 0.92(0.84,1.01) | 0.068 |
| Year of publication | Year of publication | ||||||||||
| ≥ 2015 | 9 | 92.7 | < 0.001 | 1.54(1.25,1.90) | < 0.001 | ≥ 2015 | 6 | 79.2 | < 0.001 | 0.97(0.84,1.12) | 0.709 |
| < 2015 | 4 | 58 | 0.068 | 1.70(1.45,1.98) | < 0.001 | < 2015 | 5 | 81.2 | < 0.001 | 1.01(0.80,1.28) | 0.939 |
| No. of patients | No. of patients | ||||||||||
| ≥ 500 | 8 | 93.1 | < 0.001 | 1.47(1.24,1.73) | < 0.001 | ≥ 500 | 5 | 67.3 | 0.016 | 0.96(0.84,1.09) | 0.520 |
| < 500 | 5 | 87.2 | < 0.001 | 1.92(1.29,2.87) | 0.001 | < 500 | 6 | 84.6 | < 0.001 | 1.00(0.81,1.24) | 0.971 |
| Median follow-up | Median follow-up | ||||||||||
| ≥ 36 months | 4 | 96.4 | < 0.001 | 1.55(1.02,2.37) | 0.042 | ≥ 36 months | 2 | 93.5 | < 0.001 | 1.06(0.60,1.86) | 0.838 |
| < 36 months | 6 | 65.9 | 0.012 | 1.62(1.37,1.92) | < 0.001 | < 36 months | 8 | 68.4 | 0.002 | 0.96(0.84,1.08) | 0.487 |
| LNM | ACT | ||||||||||
| Overall | 30 | 95 | < 0.001 | 1.51(1.37,1.67) | < 0.001 | Overall | 18 | 93.8 | < 0.001 | 1.16(1.00,1.34) | 0.054 |
| Geographical region | Geographical region | ||||||||||
| Asia | 11 | 61.2 | 0.004 | 1.58(1.38,1.81) | < 0.001 | Asia | 2 | 97.1 | < 0.001 | 1.16(0.41,3.31) | 0.775 |
| non-Asia | 19 | 96.2 | < 0.001 | 1.48(1.32,1.66) | < 0.001 | non-Asia | 16 | 93.4 | < 0.001 | 1.15(0.99,1.34) | 0.063 |
| Year of publication | Year of publication | ||||||||||
| ≥ 2015 | 18 | 94.9 | < 0.001 | 1.52(1.34,1.71) | < 0.001 | ≥ 2015 | 11 | 93.4 | < 0.001 | 1.12(0.92,1.37) | 0.243 |
| < 2015 | 12 | 58.6 | 0.005 | 1.50(1.38,1.64) | < 0.001 | < 2015 | 7 | 89.6 | < 0.001 | 1.21(0.99,1.48) | 0.053 |
| No. of patients | No. of patients | ||||||||||
| ≥ 500 | 14 | 98.9 | < 0.001 | 1.48(1.29,1.70) | < 0.001 | ≥ 500 | 9 | 95.7 | < 0.001 | 1.13(0.94,1.37) | 0.201 |
| < 500 | 16 | 69.1 | < 0.001 | 1.53(1.38,1.71) | < 0.001 | < 500 | 9 | 86.3 | < 0.001 | 1.18(0.93,1.50) | 0.177 |
| Median follow-up | Median follow-up | ||||||||||
| ≥ 36 months | 11 | 95.3 | < 0.001 | 1.47(1.24,1.74) | < 0.001 | ≥ 36 months | 8 | 92.4 | < 0.001 | 1.16(0.91,1.49) | 0.228 |
| < 36 months | 13 | 49.4 | 0.022 | 1.61(1.49,1.74) | < 0.001 | < 36 months | 9 | 89.9 | < 0.001 | 1.20(0.99,1.46) | 0.065 |