Table 2.
Association of previously associated variants with annual change in emphysema in candidate gene analysis
| Meta-analysis of Whites | African Americans | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Previously associated trait | Nearest gene | Chr. | Position | SNP | Risk allele | Alt. allele | Beta | SE | P | Beta | SE | P |
| %LAA-950 | ||||||||||||
| COPD,Lung function | DSP | 6 | 7563232 | rs2076295 | T | G | 0.086 | 0.021 | 3.79E-05 | 0.008 | 0.038 | 8.30E-01 |
| Lung function | LY86 | 6 | 6741932 | rs1294417 | T | C | 0.062 | 0.021 | 2.83E-03 | -0.002 | 0.041 | 9.69E-01 |
| Lung function | TGFB2 | 1 | 218631452 | rs6604614 | C | G | 0.065 | 0.022 | 3.82E-03 | 0.042 | 0.039 | 2.85E-01 |
| Lung function | BMP4 | 14 | 54419106 | rs35107139 | C | A | 0.063 | 0.022 | 4.17E-03 | -0.056 | 0.04 | 1.56E-01 |
| Lung function | GLIS2 | 16 | 4361138 | rs56104880 | C | T | 0.064 | 0.022 | 4.67E-03 | -0.009 | 0.046 | 8.52E-01 |
| COPD | VGLL4 | 3 | 11640601 | rs2442776 | G | A | 0.083 | 0.029 | 4.90E-03 | 0.075 | 0.046 | 1.04E-01 |
| Lung function | VAPA | 18 | 10078071 | rs8089099 | A | G | 0.065 | 0.023 | 5.03E-03 | 0.031 | 0.058 | 5.90E-01 |
| COPD | DENND2D | 1 | 111738108 | rs629619 | T | C | 0.07 | 0.026 | 7.57E-03 | -0.06 | 0.049 | 2.20E-01 |
| Lung function | CSF2 | 5 | 131466629 | rs3843503 | T | A | 0.053 | 0.021 | 1.17E-02 | 0.074 | 0.052 | 1.57E-01 |
| Lung function | JCAD | 10 | 30268770 | rs7914842 | G | A | 0.05 | 0.021 | 1.68E-02 | 0.11 | 0.047 | 1.92E-02 |
| Lung function | CCDC91 | 12 | 28588242 | rs7977418 | C | T | 0.049 | 0.02 | 1.80E-02 | -0.007 | 0.041 | 8.55E-01 |
| Lung function | AFAP1 | 4 | 7879027 | rs62289340 | C | T | 0.049 | 0.021 | 1.82E-02 | -0.006 | 0.049 | 9.00E-01 |
| COPD | SERP2 | 13 | 44842503 | rs9525927 | A | G | 0.059 | 0.026 | 2.40E-02 | 0.002 | 0.052 | 9.71E-01 |
| Lung function | RPAP1 | 15 | 41840238 | rs2012453 | G | A | 0.045 | 0.02 | 2.77E-02 | 0.017 | 0.039 | 6.57E-01 |
| COPD | SPPL2C | 17 | 43924200 | rs12373142 | C | G | 0.055 | 0.025 | 3.17E-02 | 0.026 | 0.099 | 7.94E-01 |
| Lung function | SUCLG2 | 3 | 67455803 | rs4132748 | C | T | 0.048 | 0.023 | 3.44E-02 | 0.005 | 0.05 | 9.12E-01 |
| Lung function | RIN3 | 14 | 93098339 | rs11621587 | G | C | 0.055 | 0.027 | 3.88E-02 | -0.007 | 0.105 | 9.45E-01 |
| Lung function | MET | 7 | 116431427 | rs193686 | T | C | 0.045 | 0.022 | 4.24E-02 | 0.008 | 0.038 | 8.37E-01 |
| Lung function | SPPL2C | 17 | 43940021 | rs79412431 | G | A | 0.052 | 0.026 | 4.30E-02 | 0.054 | 0.098 | 5.82E-01 |
| COPD | RIN3 | 14 | 93105953 | rs72699855 | G | C | 0.053 | 0.026 | 4.41E-02 | 0.018 | 0.064 | 7.76E-01 |
| Lung function | LTBP4 | 19 | 41117300 | rs34093919 | G | A | 0.193 | 0.096 | 4.56E-02 | NA | NA | NA |
| Lung function | THSD4 | 15 | 71803450 | rs62015883 | T | C | 0.054 | 0.027 | 4.68E-02 | -0.003 | 0.052 | 9.55E-01 |
| COPD | MMP3 | 11 | 102720945 | rs626750 | G | A | 0.053 | 0.027 | 4.72E-02 | 0.016 | 0.043 | 7.05E-01 |
| ALD | ||||||||||||
| COPD,Lung function | DSP | 6 | 7563232 | rs2076295 | T | G | -0.061 | 0.02 | 2.88E-03 | -0.003 | 0.037 | 9.45E-01 |
| Lung function | GLIS2 | 16 | 4361138 | rs56104880 | C | T | -0.059 | 0.022 | 7.50E-03 | -0.06 | 0.044 | 1.72E-01 |
| Lung function | THSD4 | 15 | 71803450 | rs62015883 | T | C | -0.07 | 0.027 | 9.01E-03 | -0.09 | 0.05 | 7.06E-02 |
| Emphysema | SNRPF | 12 | 96260474 | rs7957346 | C | A | -0.046 | 0.02 | 2.42E-02 | -0.027 | 0.038 | 4.87E-01 |
| Lung function | CSF2 | 5 | 131466629 | rs3843503 | T | A | -0.046 | 0.021 | 2.46E-02 | -0.038 | 0.05 | 4.45E-01 |
| Lung function | KIAA2012 | 2 | 202970250 | rs12997625 | C | T | -0.045 | 0.02 | 2.58E-02 | 0.058 | 0.043 | 1.76E-01 |
| COPD | MECOM | 3 | 168746145 | rs7642001 | G | A | -0.046 | 0.021 | 2.75E-02 | 0.044 | 0.042 | 2.97E-01 |
| Lung function | TGFB2 | 1 | 218855029 | rs28613267 | C | G | -0.044 | 0.02 | 2.82E-02 | -0.003 | 0.038 | 9.33E-01 |
| Lung function | JCAD | 10 | 30268770 | rs7914842 | G | A | -0.045 | 0.021 | 2.95E-02 | -0.021 | 0.046 | 6.48E-01 |
| Lung function | ATAD2B | 2 | 24018480 | rs13009582 | G | A | -0.044 | 0.02 | 3.05E-02 | -0.009 | 0.041 | 8.31E-01 |
| Lung function | RPAP1 | 15 | 41840238 | rs2012453 | G | A | -0.043 | 0.02 | 3.17E-02 | -0.019 | 0.038 | 6.23E-01 |
| Lung function | LTBP4 | 19 | 41117300 | rs34093919 | G | A | -0.2 | 0.095 | 3.49E-02 | NA | NA | NA |
| Lung function | IGFBP3 | 7 | 46448518 | rs17232687 | C | T | -0.041 | 0.02 | 4.12E-02 | 0.064 | 0.047 | 1.73E-01 |
| Lung function | DEFB136 | 8 | 11823332 | rs4128298 | C | T | -0.047 | 0.023 | 4.17E-02 | 0.05 | 0.047 | 2.83E-01 |
| Lung function | LY86 | 6 | 6741932 | rs1294417 | T | C | -0.042 | 0.02 | 4.18E-02 | 0.025 | 0.04 | 5.32E-01 |
| Lung function | DHDDS | 1 | 26775367 | rs9438626 | G | C | -0.049 | 0.025 | 4.81E-02 | -0.028 | 0.037 | 4.42E-01 |
| Lung function | SPAG17 | 1 | 118911295 | rs35043843 | G | T | -0.048 | 0.024 | 4.81E-02 | -0.068 | 0.051 | 1.88E-01 |
| Emphysema | SERPINA1 | 14 | 94844947 | rs28929474 | T | C | -0.129 | 0.066 | 4.95E-02 | NA | NA | NA |
%LAA-950 percentage of low-attenuation area less than -950 Hounsfield units, ALD Adjusted lung density, Chr. Chromosome, Alt.allele Alternative allele