Table 3.
Association of lung function polygenic risk score with baseline emphysema and annual change in emphysema
| Baseline emphysema | Annual change in emphysema | |||||
|---|---|---|---|---|---|---|
| Beta | SE | P | Beta | SE | P | |
| %LAA-950 | ||||||
| Meta-Analysis of Whites | 0.0103 | 0.0011 | 3.00E-19 | 0.0025 | 0.0012 | 4.03E-02 |
| COPDGene NHW | 0.0109 | 0.0014 | 1.39E-15 | 0.0018 | 0.0014 | 2.10E-01 |
| ECLIPSE White | 0.0087 | 0.0021 | 4.63E-05 | 0.0041 | 0.0022 | 6.49E-02 |
| COPDGene AA | 0.0056 | 0.0026 | 2.98E-02 | 0.0013 | 0.0028 | 6.48E-01 |
| ALD | ||||||
| Meta-Analysis of Whites | -0.0075 | 0.0011 | 2.42E-11 | -0.0021 | 0.0012 | 7.31E-02 |
| COPDGene NHW | -0.0077 | 0.0013 | 8.06E-09 | -0.0028 | 0.0014 | 4.37E-02 |
| ECLIPSE White | -0.0071 | 0.0021 | 8.33E-04 | -0.0003 | 0.0022 | 8.76E-01 |
| COPDGene AA | -0.0039 | 0.0024 | 1.06E-01 | 0.0016 | 0.0027 | 5.54E-01 |
Outcome inversely normal transformed; %LAA-950 percentage of low-attenuation area less than -950 Hounsfield units, ALD Adjusted lung density, NHW Non-Hispanic Whites, AA African Americans, ECLIPSE Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points