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. 2019 Jul 15;14:5287–5301. doi: 10.2147/IJN.S203113

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© 2019 Zhang et al.

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Characteristics of various CS NPs. (A) Size distributions of CS NPs and CS NPs-HA. a) CS NPs; b) CS NPs-HA. (B) An SEM image of CS NPs-HA. (C) Size distributions of sCS NPs and sCS NPs-HA. a) sCS NPs; b) sCS NPs-HA. (D) Cy3-labeled siRNA encapsulation efficiency of CS NPs and CS NPs-HA. A total of 0.5 μL of Cy3-labeled siRNA served as a control (CTRL); lane 1, 5.3 μL of CS NPs; lane 2, 5.3 μL of sCS NPs (containing 0.5 μL of Cy3-labeled siRNA); lane 3, 5.3 μL of CS NPs-HA; lane 4, 5.3 μL of sCS NPs-HA (containing 0.5 μL of Cy3-labeled siRNA); lane 5, 1 μL of Cy3-labeled siRNA was used as a control (CTRL); lane 6, 10.6 μL of CS NPs; lane 7, 10.6 μL of sCS NPs (containing 1 μL of Cy3-labeled siRNA); lane 8, 10.6 μL of CS NPs-HA; lane 9, 10.6 μL of sCS NPs-HA (containing 1 μL of Cy3-labeled siRNA). (E) In vitro stability of CS NPs. a) CS NPs; b) sCS NPs; c) CS NPs-HA; d) sCS NPs-HA (n=3).

Abbreviations: CS NPs, chitosan nanoparticles; CS NPs-HA, HA-modified chitosan nanoparticles; sCS NPs, chitosan nanoparticles loaded with siRNA; sCS NPsHA, HA-modified chitosan nanoparticles loaded with siRNA.