. 2019 Mar 28;104(9):3670–3678. doi: 10.1210/jc.2018-02339

Table 4.

Subcutaneous Adipose Tissue mRNA Transcript Levels in Patients Treated With Aromatase Inhibitors and in Control Subjects

	Patients (n = 20)	Control Subjects (n = 18)	P
Steroid hormone synthesis and metabolism
HSD11B1, 11βHSD1	0.91 ± 0.15	0.78 ± 0.10	NS^a
AKR1C2, aldo-keto reductase 1C2	1.01 ± 0.20	0.80 ± 0.11	NS^a
CYP19A1 aromatase	0.66 ± 0.14	0.42 ± 0.09	NS^a
Steroid hormone receptors
AR, androgen receptor	0.77 ± 0.06	0.71 ± 0.05	NS^a
ESR1, estrogen receptor α	0.74 ± 0.10	0.59 ± 0.07	NS^a
ESR2, estrogen receptor β	0.41 ± 0.03	0.42 ± 0.03	NS
Adipogenesis, lipogenesis, and lipolysis
ACACA, acetyl CoA carboxylase	0.76 ± 0.09	0.65 ± 0.11	NS
UCP2, uncoupling protein 2	0.44 ± 0.04	0.46 ± 0.03	NS^a
FASN, fatty acid synthase	0.65 ± 0.07	0.62 ± 0.07	NS
LIPE, hormone-sensitive lipase	1.28 ± 0.17	0.99 ± 0.14	NS
PLIN2, perilipin 2	0.70 ± 0.07	0.55 ± 0.05	NS
LKB1, liver kinase B1	1.44 ± 0.19	0.98 ± 0.15	0.030^a
CTNNB1, β-catenin	0.62 ± 0.04	0.45 ± 0.02	0.023
PNPLA2, adipose triglyceride lipase	0.58 ± 0.07	0.62 ± 0.08	NS^a
PPARG, peroxisome proliferator-activated receptor γ	0.91 ± 0.11	0.68 ± 0.10	NS^a
PPARGC1A, PGC-1α	0.67 ± 0.08	0.58 ± 0.08	NS
Lipid and sterol metabolism
CETP, cholesterol ester transfer protein	0.62 ± 0.14	0.90 ± 0.24	NS^a
LPL, lipoprotein lipase	1.25 ± 0.07	1.08 ± 0.14	NS^a
SREBF1, sterol regulatory element binding transcription factor 1	0.86 ± 0.10	0.70 ± 0.12	NS
SREBF2, sterol regulatory element binding transcription factor 2	0.76 ±	0.64 ±	NS^a
Adipokines
IL6, interleukin-6	0.87 ± 0.15	1.00 ± 0.20	NS^a
LEP, leptin	0.92 ± 0.10	0.55 ± 0.06	0.003^a
ADIPOQ, adiponectin	1.28 ± 0.10	1.17 ± 0.06	NS^b
Miscellaneous
IGF1R, IGF-1 receptor	0.73 ± 0.06	0.62 ± 0.04	NS
IGF1, insulin-like growth factor-1	0.67 ± 0.05	0.64 ± 0.05	NS
AGT, angiotensinogen	0.86 ± 0.08	0.95 ± 0.14	NS
ADRA2A, α-2-adrenergic receptor	0.95 ± 0.09	0.83 ± 0.11	NS^a
ARDB1, β-1-adrenergic receptor	0.74 ± 0.07	0.65 ± 0.05	NS^a

Data are presented as mean ± SEM (relative to cyclophyllin).

Abbreviation: NS, not significant.

^{^a}

Compared with independent-samples Student t test (data log transformed where not normally distributed as determined by Kolmogorov-Smirnov test).

^{^b}

Independent-samples Mann-Whitney U test where transformation did not result in normally distributed data.