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. 2019 Jul 12;25:5170–5180. doi: 10.12659/MSM.916815

Figure 1.

Figure 1

MiR-31-3p was identified to be downregulated in medullary thyroid carcinoma (MTC). (A, B) Volcano plot of dysregulated miRNAs in GSE40807 or GSE97070. (C) Venn diagram exhibiting the miRNAs that were dysregulated in both GSE40807 and GSE97070 datasets. (D, E) GEO2R analysis showing the expression of miR-31-3p in MTC and normal samples from GSE40807 and GSE97070 datasets. (F) Relative expression of miR-31-3p of 22 pairs of MTC and para-carcinoma tissues were detected by quantitative real-time polymerase chain reaction. (G) Expression of miR-31-3p was examined in 1 immortalized normal thyroid follicular cell line NThy-ori-3.1 and 2 human MTC cell lines MZ-CRC-1 and TT. (H) Overall survival rate of MTC patients with high or low miR-31-3p expression. (I) Kaplan-Meier plots showing overall survival in MTC patients with high or low miR-31-3p expression.