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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Nat Immunol. 2019 Jul 1;20(8):1071–1082. doi: 10.1038/s41590-019-0419-9

Figure 2. rN B cells are epigenetically distinct in SLE subjects.

Figure 2.

(a) Volcano plot of DML (left), DEG (middle), and DAR (right) between SLE and HC rN B cells. The number of differential features is indicated. DML represent CpG with >20% change and FDR < 0.05 as determined by DSS and DEG and DAR represent features with >=2-fold change and FDR < 0.05 as determined by edgeR. (b) Scatter plot of the correlation of DML vs. DEG (left) and DAR vs. DEG (right) for the data in a. (c) Bar plot of gene expression levels for the indicated gene. Data represent mean ±SD, * indicates DEG between SLE and HC (>=2-fold change and FDR < 0.05) as determined by edgeR. (d) Genome plot showing the average accessibility levels in each cell type at the indicated loci. Data represent the mean for each cell type from one experiment. DAR between HC and SLE rN B cells are highlighted with a box. See also Supplementary Fig. 4.