Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Magn Reson Imaging. 2019 Jan 20;50(3):868–877. doi: 10.1002/jmri.26651

Table 2.

Multivariate analysis of risk factors for CMB burden.

Risk factors for CMB development
Univariate Poisson
Analysis
Multivariate Poisson Analysisa
Characteristic Incidence Rate
Ratio
P-value Incidence Rate Ratio P-value
Time since RT, each additional year 1.05 (1.02, 1.09) <.001 1.10 (1.04, 1.16) <.001
>1 surgical resection 1.98 (1.12, 3.51) .022 2.42 (1.36, 4.30) .004
Tumor pathology
Glioblastoma vs anaplastic astrocytoma 2.69 (1.29, 5.61) .010 2.41 (1.21, 4.77) .014
Glioblastoma vs other 1.25 (.464, 3.37) .661 .257 (.064, 1.04) .060
Tumor location
Frontal vs temporal .454 (.188, 1.10) .083 .445 (.213, .932) .035
Frontal vs parietal .353 (.066, 1.87) .225 .204 (.046, .900) .039
Frontal vs occipital, cerebellum or brainstem 1.11 (.413, 2.97) .840 3.58 (1.20, 10.6) .025
Maximum brain radiation, each additional Gyb 1.00 (.999,1.00) .579 not included as significant
Type of SWI acquired
Multi-echo vs single-echo SWIc .534 (.291, .980) .046 .717 (.425, 1.21) .217
a

race, sex, and age at time of RT included as covariates.

b

37 subjects

c

difference in slice thickness: 1mm for single echo SWI and 2mm for multi-echo SWI.